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Alzheimer's: Type 3 diabetes?

2017-05-02 17:58:10.619619+00 by Dan Lyke 2 comments

This looks like a strong step forward: Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed

... Altogether, the data provide strong evidence that AD is intrinsically a neuroendocrine disease caused by selective impairments in insulin and IGF signaling mechanisms, including deficiencies in local insulin and IGF production. At the same time, it is essential to recognize that T2DM and T3DM are not solely the end results of insulin/IGF resistance and/or deficiency, because these syndromes are unequivocally accompanied by significant activation of inflammatory mediators, oxidative stress, DNA damage, and mitochondrial dysfunction, which contribute to the degenerative cascade by exacerbating insulin/ IGF resistance. Referring to AD as T3DM is justified, because the fundamental molecular and biochemical abnormalities overlap with T1DM and T2DM rather than mimic the effects of either one. ...

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#Comment Re: Alzheimer's: Type 3 diabetes? made: 2017-05-03 08:09:13.858543+00 by: topspin

A good read but the PPAR-gamma agonists, thiazolidinediones like Avandia (rosiglitazone was mentioned as the PPAR they studied to blunt the degenerative effects,) are linked to various cardiac issues. Perhaps the intra-nasal insulin is the key. Interesting, especially to those of us who have a family history of Alzheimer's Disease AND flirt with metabolic syndrome.

#Comment Re: Alzheimer's: Type 3 diabetes? made: 2017-05-13 01:55:57.881917+00 by: meuon

Unlike Topspin, I don't understand the chemistry, but it makes sense that it's part of that family of problems.

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