That's Nuts!
2018-01-09 17:33:37.87155+00 by Dan Lyke 0 comments
Taking ibuprofen for long periods found to alter human testicular physiology
The researchers report that just two weeks into the study, they found that all of the volunteers had an increase in luteinizing hormones, which the male body uses to regulate the production of testosterone. The increase indicated that the drug was causing problems in certain cells in the testicles, preventing them from producing testosterone, which is, of course, needed to produce sperm cells. They further report that the change caused the pituitary gland to respond by producing more of another hormone, which forced the body to produce more testosterone. The net result was that overall testosterone levels remained constant, but the body was overstressing to compensate for the detrimental impact of the Ibuprofen—a state called compensated hypogonadism.
David Møbjerg Kristensen et al. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1715035115