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autism & allopregnanolone?

2019-10-28 15:09:13.337449+00 by Dan Lyke 0 comments

Autism spectrum disorder risk linked to insufficient placental steroid

CHICAGO-A study in experimental models suggests that allopregnanolone, one of many hormones produced by the placenta during pregnancy, is so essential to normal fetal brain development that when provision of that hormone decreases or stops abruptly - as occurs with premature birth - offspring are more likely to develop autism-like behaviors. A Children's National Hospital research team reports the findings Oct. 20, 2019, at the Neuroscience 2019 annual meeting.

"To our knowledge, no other research team has studied how placental allopregnanolone (ALLO) contributes to brain development and long-term behaviors," says Claire-Marie Vacher, Ph.D., lead author. "Our study finds that targeted loss of ALLO in the womb leads to long-term structural alterations of the cerebellum - a brain region that is essential for motor coordination, balance and social cognition - and increases the risk of developing autism," Vacher says.

[ related topics: Children and growing up ]

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