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latest hydroxychloroquine study

2020-04-21 20:03:46.582734+00 by Dan Lyke 9 comments

Maybe now we can stop killing people with hydroxychloroquine studies? More deaths, no benefit from malaria drug in VA virus study

With 368 patients, the study is the largest look so far of hydroxychloroquine with or without the antibiotic azithromycin for Covid-19.

More deaths, no benefit from malaria drug in VA virus study

[ related topics: Health virus Current Events Gambling ]

comments in ascending chronological order (reverse):

#Comment Re: latest hydroxychloroquine study made: 2020-04-22 10:41:37.019515+00 by: TheSHAD0W [edit history]

https://www.medrxiv.org/content/10.1101/2020.04.16.20065920v1

#Comment Re: latest hydroxychloroquine study made: 2020-04-22 15:49:08.324292+00 by: Dan Lyke

Yeah, it's one in a long chain that's not showing any positive effect: https://www.cebm.net/covid-19/...-do-the-clinical-trials-tell-us/

#Comment Re: latest hydroxychloroquine study made: 2020-04-24 16:36:52.08831+00 by: Dan Lyke

And another one: https://www.cnbc.com/2020/04/2...-short-over-safety-concerns.html

#Comment Re: latest hydroxychloroquine study made: 2020-04-25 22:09:27.209397+00 by: TheSHAD0W

RTFP:

#Comment Re: latest hydroxychloroquine study made: 2020-05-03 22:31:17.732254+00 by: TheSHAD0W

Gonna dump this here, in case anyone wants to read into it:

----------------------------------------------------------------------------------

HCQ has 4 mechanisms of action:

It binds the GBD of the spike protein preventing binding with the ACE2 receptor

https://www.sciencedirect.com/...ce/article/pii/S0924857920301102

It is known to block virus infection by increasing endosomal pH required for virus/cell fusion

https://www.nature.com/article...0ygN1LtI67SkcgREM4DyxxAcPauRuf5w

It has an anti-inflammatory effect which is protective against cytokine storm

https://europepmc.org/article/med/8336306

It is a zinc ionophore allowing for higher levels of zinc to enter the cell which inhibits RNA polymerase.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/

------------------

IN VIVO DATA:

17 March 2020 : First Paper published, N-count 20 - 100% cured totally, 6 days of pills

https://files.catbox.moe/h5tyv6.pdf

27 March 2020 : Second Paper published, N-count 80 - 99% of dying cured totally, 8 days of pills

https://www.mediterranee-infec...ploads/2020/03/COVID-IHU-2-1.pdf

9 April 2020 : Third Paper abstract, N-count 1,061 - 91.7%% of semi-sick cured, 3 days of pills

https://www.mediterranee-infec...arlyTrtCovid19_09042020_vD1v.pdf

1 May 2020: HCQ application is associated with a decreased mortality in critically ill patients with COVID-19 (Mortality: 45.8% control vs 18.8% with HCQ)

https://www.medrxiv.org/conten...1/2020.04.27.20073379v1.full.pdf

---------------

#Comment Re: latest hydroxychloroquine study made: 2020-05-09 16:55:24.603076+00 by: Dan Lyke

Another one https://time.com/5833945/hydroxychloroquine-coronavirus-study/ https://www.nejm.org/doi/full/.../NEJMoa2012410?query=main_nav_lg

#Comment Re: latest hydroxychloroquine study made: 2020-05-10 00:49:50.841072+00 by: TheSHAD0W

And again, no zinc, though the dosage appears to be what's been suggested elsewhere. Also, no azithromycin.

#Comment Re: latest hydroxychloroquine study made: 2020-05-16 18:32:17.231317+00 by: Dan Lyke

Drug promoted by Trump as coronavirus ‘game changer’ increasingly linked to deaths

For two months, President Trump repeatedly pitched hydroxychloroquine as a safe and effective treatment for coronavirus, asking would-be patients “What the hell do you have to lose?”

Growing evidence shows that, for many, the answer is their lives.

#Comment Re: latest hydroxychloroquine study made: 2020-05-17 02:20:00.345084+00 by: TheSHAD0W

The article mostly references the studies previously noted here, with the defects in those studies I mentioned. The one item not mentioned is a paper regarding long-QT syndrome with patients using HCQ. https://www.medrxiv.org/content/10.1101/2020.04.02.20047050v1

Examination of the paper shows no data on dosages used, whether varying dosages were used and if so, no correlation between dosages and detected increase in QT timing. HCQ is known to exacerbate long-QT syndrome and should be administered under supervision - though it's been available OTC outside the US for a long time.

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