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Painkillers & pain

2022-05-13 00:48:14.807396+02 by Dan Lyke 0 comments

Turns out anti-inflammatory painkillers likely make you heal more slowly: Acute inflammatory response via neutrophil activation protects against the development of chronic pain DOI: 10.1126/scitranslmed.abj9954

Together, our results suggest that active immune processes confer adaptation at the acute pain stage, and impairment of such inflammatory responses in subjects with acute LBP (or TMD) increases the risk of developing chronic pain. These adaptive inflammatory responses are intrinsically transcriptionally driven, probably modified by both genetics and environmental factors, and can be inhibited by steroids and NSAIDs.

Now I have a paper to cite next emergency room visit when they ask me why I don't want painkillers, aside from the whole "I hate the feeling of what they do to my jaw muscles".

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