Flutterby™! : COVID-19 and weakened immune systems

World Health Network: WHN Science Communications — COVID-19 and Immune Dysregulation, a Summary and Resource

COVID-19 infection has several very concerning effects on the immune system that might easily lead to advantages for other pathogens as well as worse outcomes in COVID-19 reinfections. This immune dysfunction or aging is at least one of the most likely scenarios explaining the recent surges in diseases like RSV, influenza, Strep A, and other infections. By contrast, immunity debt is not considered a viable explanation as the surges of these diseases continue in countries that had surges last season and immunity wanes for many of these diseases. Another serious concern at this point is that repeated infections by COVID-19 might lead to depletion or exhaustion of cytotoxic CD8+ T cells which could have downstream effects on other diseases like cancers, as these T cells are instrumental in limiting tumor proliferation and have been shown to differentiate to become dysfunctional.